Convenient synthesis of arylboronates through a synergistic Pd/Cu-catalyzed miyaura borylation reaction under atmospheric conditions

A highly efficient and practical borylation reaction of aryl iodides with bis(pinacolato)diboron has been established. By using Pd(OAc)₂, CuI, and PPh₃ as a ligand at room temperature under air in the presence of Cs₂CO₃, the protocol proved to be general. Various functionalized arylboronates were obtained in moderate to excellent yields. In addition, a possible reaction mechanism was proposed. An efficient borylation reaction of aryl iodides with bis(pinacolato)diboron is developed by using Pd(OAc)₂ and CuI. This catalytic system has high catalytic efficiency at room temperature in air and functional-group tolerance for a wide range of substrates.