Complete Blood Count Markers of Infection in Anti-interferon-γ Autoantibody-Associated Immunodeficiency with Reactive Dermatoses

Objective: To identify clinical and laboratory parameters associated with infections in patients with reactive dermatoses. Materials and Methods: This retrospective study reviewed the medical records of patients diagnosed with adult-onset immunodeficiency syndrome caused by anti-interferon-gamma autoantibodies. Clinical data, laboratory findings, and information on concurrent infections were analyzed. Results: Of the 147 patients reviewed, 62 (42.2%) presented with reactive dermatoses, accounting for 135 episodes. Patients with concurrent infections had significantly lower mean corpuscular volume (78.5 vs. 84.9 fL; p=0.039). In contrast, red cell distribution width (16.2 vs. 14.1%; p=0.005), white blood cell count (20.96 vs. 15.56 ×10³/μL; p=0.037), absolute neutrophil count (15.76 vs. 11.14 ×10³/μL; p=0.038), and platelet count (414.5 vs. 376.0 ×10³/μL; p=0.023), were significantly higher in infected episodes than in non-infected episodes. Conclusion: In patients presenting with reactive dermatoses, laboratory parameters derived from the routine complete blood count can serve as valuable indicators of increased risk for concurrent infections, enabling prompt diagnosis and targeted management.