Complement and its role in protection and pathogenesis of flavivirus infections

Panisadee Avirutnan; Erin Mehlhop; Michael S. Diamond

doi:10.1016/j.vaccine.2008.11.061

Complement and its role in protection and pathogenesis of flavivirus infections

Panisadee Avirutnan
, Erin Mehlhop
, Michael S. Diamond

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Washington University School of Medicine in St. Louis

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.

Original language	English
Pages (from-to)	I100-I107
Journal	Vaccine
Volume	26
Issue number	SUPPL. 8
DOIs	https://doi.org/10.1016/j.vaccine.2008.11.061
Publication status	Published - 30 Dec 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Virus, Innate Immunity, Dengue, West Nile, Immune Evasion

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10.1016/j.vaccine.2008.11.061

Cite this

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ER -

Complement and its role in protection and pathogenesis of flavivirus infections

Abstract

UN SDGs

Keywords

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