Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand

Noppawan Tunsirimas; Pornjira Pariwatcharakul; Somrak Choovanichvong; Woraphat Ratta-apha

doi:10.1016/j.ajp.2019.03.002

Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand

Noppawan Tunsirimas
, Pornjira Pariwatcharakul
, Somrak Choovanichvong
, Woraphat Ratta-apha

Department of Psychiatry

Siriraj Hospital
Nakorn Ratchasima Rajanagarindra Psychiatric Hospital
Srithanya Hospital

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The present study aimed to investigate the incidence of agranulocytosis and leukopenia and its associated factors in Thai schizophrenia patients treated with clozapine and the rate of hematologic adverse events monitored in clinical practice. Data were collected from the medical records of 641 outpatients at two hospitals. The results showed no cases of agranulocytosis and 20 cases of leukopenia (3.1%), 85% of which were observed after 1 year of prescription. The associated factors were female (p = 0.019) and duration of clozapine prescription (p = 0.026). According to the guideline for safety monitoring, 23.6% of cases had neutrophils count monitoring.

Original language	English
Pages (from-to)	13-16
Number of pages	4
Journal	Asian Journal of Psychiatry
Volume	41
DOIs	https://doi.org/10.1016/j.ajp.2019.03.002
Publication status	Published - Mar 2019

Keywords

Agranulocytosis
Clozapine
Leukopenia
Schizophrenia

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10.1016/j.ajp.2019.03.002

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title = "Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand",

abstract = "The present study aimed to investigate the incidence of agranulocytosis and leukopenia and its associated factors in Thai schizophrenia patients treated with clozapine and the rate of hematologic adverse events monitored in clinical practice. Data were collected from the medical records of 641 outpatients at two hospitals. The results showed no cases of agranulocytosis and 20 cases of leukopenia (3.1\%), 85\% of which were observed after 1 year of prescription. The associated factors were female (p = 0.019) and duration of clozapine prescription (p = 0.026). According to the guideline for safety monitoring, 23.6\% of cases had neutrophils count monitoring.",

keywords = "Agranulocytosis, Clozapine, Leukopenia, Schizophrenia",

author = "Noppawan Tunsirimas and Pornjira Pariwatcharakul and Somrak Choovanichvong and Woraphat Ratta-apha",

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Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand. / Tunsirimas, Noppawan; Pariwatcharakul, Pornjira; Choovanichvong, Somrak et al.
In: Asian Journal of Psychiatry, Vol. 41, 03.2019, p. 13-16.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clozapine-induced agranulocytosis and leukopenia

T2 - Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand

AU - Tunsirimas, Noppawan

AU - Pariwatcharakul, Pornjira

AU - Choovanichvong, Somrak

AU - Ratta-apha, Woraphat

PY - 2019/3

Y1 - 2019/3

N2 - The present study aimed to investigate the incidence of agranulocytosis and leukopenia and its associated factors in Thai schizophrenia patients treated with clozapine and the rate of hematologic adverse events monitored in clinical practice. Data were collected from the medical records of 641 outpatients at two hospitals. The results showed no cases of agranulocytosis and 20 cases of leukopenia (3.1%), 85% of which were observed after 1 year of prescription. The associated factors were female (p = 0.019) and duration of clozapine prescription (p = 0.026). According to the guideline for safety monitoring, 23.6% of cases had neutrophils count monitoring.

AB - The present study aimed to investigate the incidence of agranulocytosis and leukopenia and its associated factors in Thai schizophrenia patients treated with clozapine and the rate of hematologic adverse events monitored in clinical practice. Data were collected from the medical records of 641 outpatients at two hospitals. The results showed no cases of agranulocytosis and 20 cases of leukopenia (3.1%), 85% of which were observed after 1 year of prescription. The associated factors were female (p = 0.019) and duration of clozapine prescription (p = 0.026). According to the guideline for safety monitoring, 23.6% of cases had neutrophils count monitoring.

KW - Agranulocytosis

KW - Clozapine

KW - Leukopenia

KW - Schizophrenia

UR - https://www.scopus.com/pages/publications/85062495210

U2 - 10.1016/j.ajp.2019.03.002

DO - 10.1016/j.ajp.2019.03.002

M3 - Article

C2 - 30856469

AN - SCOPUS:85062495210

SN - 1876-2018

VL - 41

SP - 13

EP - 16

JO - Asian Journal of Psychiatry

JF - Asian Journal of Psychiatry

ER -

Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand

Abstract

Keywords

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