Abstract
A novel ofloxacin-oxalic acid complex was prepared by the cogrinding method. The obtained complex was characterized by powder X-ray diffraction (PXRD), infrared (IR), solid-state nuclear magnetic resonance (NMR), and terahertz (THz) spectroscopy. The PXRD measurement revealed that the ofloxacin-oxalic acid complex induced by cogrinding was formed at a molar ratio of 1:2. Weak interaction between two components, not a hydrogen bonding, was found by IR and solid-state NMR spectroscopy. The distinctive THz spectrum showed that the vibrational modes of the complex were different from those of the starting materials, suggesting that THz spectroscopy is an alternative tool to evaluate complex formation through weak interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 50-55 |
| Number of pages | 6 |
| Journal | International Journal of Pharmaceutics |
| Volume | 382 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 1 Dec 2009 |
| Externally published | Yes |
Keywords
- Complex
- Grinding
- Ofloxacin
- Oxalic acid
- Terahertz time-domain spectroscopy
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