Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells

Liying Wang; Sudjit Luanpitpong; Vincent Castranova; William Tse; Yongju Lu; Varisa Pongrakhananon; Yon Rojanasakul

doi:10.1021/nl2011214

Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells

Liying Wang
, Sudjit Luanpitpong
, Vincent Castranova
, William Tse
, Yongju Lu
, Varisa Pongrakhananon
, Yon Rojanasakul

National Institute for Occupational Safety and Health
West Virginia University

Research output: Contribution to journal › Article › peer-review

140 Citations (Scopus)

Abstract

Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.

Original language	English
Pages (from-to)	2796-2803
Number of pages	8
Journal	Nano Letters
Volume	11
Issue number	7
DOIs	https://doi.org/10.1021/nl2011214
Publication status	Published - 13 Jul 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Single-walled carbon nanotubes
apoptosis
carcinogenesis
lung
malignant transformation

Access to Document

10.1021/nl2011214

Cite this

@article{588377e17e2a4d4e9d63730b8c7bad29,

title = "Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells",

abstract = "Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.",

keywords = "Single-walled carbon nanotubes, apoptosis, carcinogenesis, lung, malignant transformation",

author = "Liying Wang and Sudjit Luanpitpong and Vincent Castranova and William Tse and Yongju Lu and Varisa Pongrakhananon and Yon Rojanasakul",

year = "2011",

month = jul,

day = "13",

doi = "10.1021/nl2011214",

language = "English",

volume = "11",

pages = "2796--2803",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "7",

}

TY - JOUR

T1 - Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells

AU - Wang, Liying

AU - Luanpitpong, Sudjit

AU - Castranova, Vincent

AU - Tse, William

AU - Lu, Yongju

AU - Pongrakhananon, Varisa

AU - Rojanasakul, Yon

PY - 2011/7/13

Y1 - 2011/7/13

N2 - Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.

AB - Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.

KW - Single-walled carbon nanotubes

KW - apoptosis

KW - carcinogenesis

KW - lung

KW - malignant transformation

UR - https://www.scopus.com/pages/publications/79960265384

U2 - 10.1021/nl2011214

DO - 10.1021/nl2011214

M3 - Article

C2 - 21657258

AN - SCOPUS:79960265384

SN - 1530-6984

VL - 11

SP - 2796

EP - 2803

JO - Nano Letters

JF - Nano Letters

IS - 7

ER -

Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this