Cannabinoid receptor 1 (CB 1R) expression in rat dental pulp

Somsak Mitrirattanakul; Sopee Poomsawat; Pornpoj Fuangtharnthip

doi:10.1016/S1348-8643(12)00003-1

Cannabinoid receptor 1 (CB ₁R) expression in rat dental pulp

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Purpose of the research: Accumulating evidence supports the role of the cannabinoid system in providing an antinociceptive effect in various painful conditions. This effect is mediated through the Cannabinoid receptor 1 (CB1R) expressed on nociceptive afferent nerve terminals. To investigate whether this receptor plays a similar role in dental pain, we studied the presence and distribution of CB1R in rat dental pulp. Pulps from 28 maxillary molars were immunohistochemically stained with an antibody against CB1R. Principal results: Of all tooth specimens, CB1R immunoreactivity (CB1R-ir) was observed to be associated with nerve fibers in radicular pulp and was seen as a continuous network in the subodontoblastic layer. Major conclusion: CB1R was present on nerve fibers in rat dental pulp and possibly plays a role in dental pain mechanisms.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Oral Science International
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/S1348-8643(12)00003-1
Publication status	Published - May 2012

Keywords

Cannabinoid system
Dental pulp
Immunohistochemistry

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10.1016/S1348-8643(12)00003-1

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title = "Cannabinoid receptor 1 (CB 1R) expression in rat dental pulp",

abstract = "Purpose of the research: Accumulating evidence supports the role of the cannabinoid system in providing an antinociceptive effect in various painful conditions. This effect is mediated through the Cannabinoid receptor 1 (CB1R) expressed on nociceptive afferent nerve terminals. To investigate whether this receptor plays a similar role in dental pain, we studied the presence and distribution of CB1R in rat dental pulp. Pulps from 28 maxillary molars were immunohistochemically stained with an antibody against CB1R. Principal results: Of all tooth specimens, CB1R immunoreactivity (CB1R-ir) was observed to be associated with nerve fibers in radicular pulp and was seen as a continuous network in the subodontoblastic layer. Major conclusion: CB1R was present on nerve fibers in rat dental pulp and possibly plays a role in dental pain mechanisms.",

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author = "Somsak Mitrirattanakul and Sopee Poomsawat and Pornpoj Fuangtharnthip",

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doi = "10.1016/S1348-8643(12)00003-1",

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T1 - Cannabinoid receptor 1 (CB 1R) expression in rat dental pulp

AU - Mitrirattanakul, Somsak

AU - Poomsawat, Sopee

AU - Fuangtharnthip, Pornpoj

PY - 2012/5

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AB - Purpose of the research: Accumulating evidence supports the role of the cannabinoid system in providing an antinociceptive effect in various painful conditions. This effect is mediated through the Cannabinoid receptor 1 (CB1R) expressed on nociceptive afferent nerve terminals. To investigate whether this receptor plays a similar role in dental pain, we studied the presence and distribution of CB1R in rat dental pulp. Pulps from 28 maxillary molars were immunohistochemically stained with an antibody against CB1R. Principal results: Of all tooth specimens, CB1R immunoreactivity (CB1R-ir) was observed to be associated with nerve fibers in radicular pulp and was seen as a continuous network in the subodontoblastic layer. Major conclusion: CB1R was present on nerve fibers in rat dental pulp and possibly plays a role in dental pain mechanisms.

KW - Cannabinoid system

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KW - Immunohistochemistry

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Cannabinoid receptor 1 (CB ₁R) expression in rat dental pulp

Abstract

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