C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene

S. Ekthawatchai; S. Kamchonwongpaisan; P. Kongsaeree; B. Tarnchompoo; Y. Thebtaranonth; Y. Yuthavong

doi:10.1021/jm0103007

C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene

S. Ekthawatchai
, S. Kamchonwongpaisan
, P. Kongsaeree
, B. Tarnchompoo
, Y. Thebtaranonth
, Y. Yuthavong

Mahidol University
National Science and Technology Development Agency (NSTDA)

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grgnard reagents to artemisitene provided C-16-derived artemisinin monomers, dmers, trimers, and tetramers whose antimalarial and cytotoxic have been evaluated.

Original language	English
Pages (from-to)	4688-4695
Number of pages	8
Journal	Journal of Medicinal Chemistry
Volume	44
Issue number	26
DOIs	https://doi.org/10.1021/jm0103007
Publication status	Published - 20 Dec 2001
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1021/jm0103007

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Ekthawatchai, S., Kamchonwongpaisan, S., Kongsaeree, P., Tarnchompoo, B., Thebtaranonth, Y., & Yuthavong, Y. (2001). C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene. Journal of Medicinal Chemistry, 44(26), 4688-4695. https://doi.org/10.1021/jm0103007

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title = "C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene",

abstract = "Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grgnard reagents to artemisitene provided C-16-derived artemisinin monomers, dmers, trimers, and tetramers whose antimalarial and cytotoxic have been evaluated.",

author = "S. Ekthawatchai and S. Kamchonwongpaisan and P. Kongsaeree and B. Tarnchompoo and Y. Thebtaranonth and Y. Yuthavong",

year = "2001",

month = dec,

day = "20",

doi = "10.1021/jm0103007",

language = "English",

volume = "44",

pages = "4688--4695",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

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Ekthawatchai, S, Kamchonwongpaisan, S, Kongsaeree, P, Tarnchompoo, B, Thebtaranonth, Y & Yuthavong, Y 2001, 'C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene', Journal of Medicinal Chemistry, vol. 44, no. 26, pp. 4688-4695. https://doi.org/10.1021/jm0103007

C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene. / Ekthawatchai, S.; Kamchonwongpaisan, S.; Kongsaeree, P. et al.
In: Journal of Medicinal Chemistry, Vol. 44, No. 26, 20.12.2001, p. 4688-4695.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - C-16 artemisinin derivatives and their antimalarial and cytotoxic activities

T2 - Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene

AU - Ekthawatchai, S.

AU - Kamchonwongpaisan, S.

AU - Kongsaeree, P.

AU - Tarnchompoo, B.

AU - Thebtaranonth, Y.

AU - Yuthavong, Y.

PY - 2001/12/20

Y1 - 2001/12/20

N2 - Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grgnard reagents to artemisitene provided C-16-derived artemisinin monomers, dmers, trimers, and tetramers whose antimalarial and cytotoxic have been evaluated.

AB - Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grgnard reagents to artemisitene provided C-16-derived artemisinin monomers, dmers, trimers, and tetramers whose antimalarial and cytotoxic have been evaluated.

UR - https://www.scopus.com/pages/publications/0035924213

U2 - 10.1021/jm0103007

DO - 10.1021/jm0103007

M3 - Article

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AN - SCOPUS:0035924213

SN - 0022-2623

VL - 44

SP - 4688

EP - 4695

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 26

ER -

C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene

Abstract

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