Bridged tricyclic sesquiterpenes from the tubercle nudibranch Phyllidia coelestis Bergh

Sunan Jaisamut; Samran Prabpai; Chompoonuch Tancharoen; Supreeya Yuenyongsawad; Supa Hannongbua; Palangpon Kongsaeree; Anuchit Plubrukarn

doi:10.1021/np4007074

Bridged tricyclic sesquiterpenes from the tubercle nudibranch Phyllidia coelestis Bergh

Sunan Jaisamut
, Samran Prabpai
, Chompoonuch Tancharoen
, Supreeya Yuenyongsawad
, Supa Hannongbua
, Palangpon Kongsaeree
, Anuchit Plubrukarn

Prince of Songkla University
Mahidol University
Kasetsart University

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A new sesquiterpene, 1-formamido-10(1→2)-abeopupukeanane (1), was isolated from the tubercle nudibranch Phyllidia coelestis Bergh, along with 2-formamidopupukeanane (2), which is reported here as a natural product for the first time. A rearrangement pathway toward the unprecedented tricyclo[4.4.0.0^2,8]decane skeleton is proposed. Both compounds showed antiproliferative activity when targeting HeLa, MCF-7, KB, and HT-29 cancer cell lines in the range 0.05-10 μM.

Original language	English
Pages (from-to)	2158-2161
Number of pages	4
Journal	Journal of Natural Products
Volume	76
Issue number	11
DOIs	https://doi.org/10.1021/np4007074
Publication status	Published - 22 Nov 2013
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1021/np4007074

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title = "Bridged tricyclic sesquiterpenes from the tubercle nudibranch Phyllidia coelestis Bergh",

abstract = "A new sesquiterpene, 1-formamido-10(1→2)-abeopupukeanane (1), was isolated from the tubercle nudibranch Phyllidia coelestis Bergh, along with 2-formamidopupukeanane (2), which is reported here as a natural product for the first time. A rearrangement pathway toward the unprecedented tricyclo[4.4.0.02,8]decane skeleton is proposed. Both compounds showed antiproliferative activity when targeting HeLa, MCF-7, KB, and HT-29 cancer cell lines in the range 0.05-10 μM.",

author = "Sunan Jaisamut and Samran Prabpai and Chompoonuch Tancharoen and Supreeya Yuenyongsawad and Supa Hannongbua and Palangpon Kongsaeree and Anuchit Plubrukarn",

year = "2013",

month = nov,

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doi = "10.1021/np4007074",

language = "English",

volume = "76",

pages = "2158--2161",

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AU - Jaisamut, Sunan

AU - Prabpai, Samran

AU - Tancharoen, Chompoonuch

AU - Yuenyongsawad, Supreeya

AU - Hannongbua, Supa

AU - Kongsaeree, Palangpon

AU - Plubrukarn, Anuchit

PY - 2013/11/22

Y1 - 2013/11/22

N2 - A new sesquiterpene, 1-formamido-10(1→2)-abeopupukeanane (1), was isolated from the tubercle nudibranch Phyllidia coelestis Bergh, along with 2-formamidopupukeanane (2), which is reported here as a natural product for the first time. A rearrangement pathway toward the unprecedented tricyclo[4.4.0.02,8]decane skeleton is proposed. Both compounds showed antiproliferative activity when targeting HeLa, MCF-7, KB, and HT-29 cancer cell lines in the range 0.05-10 μM.

AB - A new sesquiterpene, 1-formamido-10(1→2)-abeopupukeanane (1), was isolated from the tubercle nudibranch Phyllidia coelestis Bergh, along with 2-formamidopupukeanane (2), which is reported here as a natural product for the first time. A rearrangement pathway toward the unprecedented tricyclo[4.4.0.02,8]decane skeleton is proposed. Both compounds showed antiproliferative activity when targeting HeLa, MCF-7, KB, and HT-29 cancer cell lines in the range 0.05-10 μM.

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VL - 76

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EP - 2161

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Bridged tricyclic sesquiterpenes from the tubercle nudibranch Phyllidia coelestis Bergh

Abstract

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