Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.

Supaluk Prachayasittikul; Patumporn Manam; Maneekarn Chinworrungsee; Chartchalerm Isarankura-Na-ayudhya; Somsak Ruchirawat; Virapong Prachayasittikul

doi:10.3390/molecules14114414

Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.

Supaluk Prachayasittikul
, Patumporn Manam
, Maneekarn Chinworrungsee
, Chartchalerm Isarankura-Na-ayudhya
, Somsak Ruchirawat
, Virapong Prachayasittikul

Clinical Microbiology and Applied Technology Department

Srinakharinwirot University
Chulabhorn Research Institute
Mahidol University

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.

Original language	English
Pages (from-to)	4414-4424
Number of pages	11
Journal	Molecules
Volume	14
Issue number	11
DOIs	https://doi.org/10.3390/molecules14114414
Publication status	Published - Nov 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimalarial and cytotoxic activities
Antimicrobial
Azafluorenone
Onychine
Polyalthia debilis

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10.3390/molecules14114414

Cite this

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title = "Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet \& Gagnep.",

abstract = "This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.",

keywords = "Antimalarial and cytotoxic activities, Antimicrobial, Azafluorenone, Onychine, Polyalthia debilis",

author = "Supaluk Prachayasittikul and Patumporn Manam and Maneekarn Chinworrungsee and Chartchalerm Isarankura-Na-ayudhya and Somsak Ruchirawat and Virapong Prachayasittikul",

year = "2009",

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doi = "10.3390/molecules14114414",

language = "English",

volume = "14",

pages = "4414--4424",

journal = "Molecules",

issn = "1420-3049",

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AU - Prachayasittikul, Supaluk

AU - Manam, Patumporn

AU - Chinworrungsee, Maneekarn

AU - Isarankura-Na-ayudhya, Chartchalerm

AU - Ruchirawat, Somsak

AU - Prachayasittikul, Virapong

PY - 2009/11

Y1 - 2009/11

N2 - This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.

AB - This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.

KW - Antimalarial and cytotoxic activities

KW - Antimicrobial

KW - Azafluorenone

KW - Onychine

KW - Polyalthia debilis

UR - https://www.scopus.com/pages/publications/73349142009

U2 - 10.3390/molecules14114414

DO - 10.3390/molecules14114414

M3 - Article

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AN - SCOPUS:73349142009

SN - 1420-3049

VL - 14

SP - 4414

EP - 4424

JO - Molecules

JF - Molecules

IS - 11

ER -

Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.

Abstract

UN SDGs

Keywords

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