Baseline levels of plasma endothelin-1 (ET-1) and changes during transfusion in thalassemic patients

Vip Viprakasit; Suthida Kankirawatana; Pravit Akarasereenont; Kritvikrom Durongpisitkul; Sirikul Chotewuttakorn; Voravarn S. Tanphaichitr

doi:10.1002/ajh.10129

Baseline levels of plasma endothelin-1 (ET-1) and changes during transfusion in thalassemic patients

Vip Viprakasit
, Suthida Kankirawatana
, Pravit Akarasereenont
, Kritvikrom Durongpisitkul
, Sirikul Chotewuttakorn
, Voravarn S. Tanphaichitr

University of Oxford
John Radcliffe Hospital
Oxford University Clinical Academic Graduate School
Siriraj Hospital

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

We studied levels of plasma endothelin-1 (ET-1) in 25 β-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 ± 2.1 pg/mL vs. 8.9 ± 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to slightly increase during the first 24 hr but significantly decline at the 7^th day to levels (8.01 ± 1.7 pg/mL) which do not differ from those of controls. This study highlights a different alteration of plasma ET-1 in patients with β-thalassemia compared to that of patients with sickle-cell anemia.

Original language	English
Pages (from-to)	260-262
Number of pages	3
Journal	American Journal of Hematology
Volume	70
Issue number	3
DOIs	https://doi.org/10.1002/ajh.10129
Publication status	Published - 2002

Keywords

Hb E disease
Plasma endothelin-1
Transfusion
β-thalassemia

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10.1002/ajh.10129

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title = "Baseline levels of plasma endothelin-1 (ET-1) and changes during transfusion in thalassemic patients",

abstract = "We studied levels of plasma endothelin-1 (ET-1) in 25 β-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 ± 2.1 pg/mL vs. 8.9 ± 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to slightly increase during the first 24 hr but significantly decline at the 7th day to levels (8.01 ± 1.7 pg/mL) which do not differ from those of controls. This study highlights a different alteration of plasma ET-1 in patients with β-thalassemia compared to that of patients with sickle-cell anemia.",

keywords = "Hb E disease, Plasma endothelin-1, Transfusion, β-thalassemia",

author = "Vip Viprakasit and Suthida Kankirawatana and Pravit Akarasereenont and Kritvikrom Durongpisitkul and Sirikul Chotewuttakorn and Tanphaichitr, \{Voravarn S.\}",

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AU - Viprakasit, Vip

AU - Kankirawatana, Suthida

AU - Akarasereenont, Pravit

AU - Durongpisitkul, Kritvikrom

AU - Chotewuttakorn, Sirikul

AU - Tanphaichitr, Voravarn S.

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AB - We studied levels of plasma endothelin-1 (ET-1) in 25 β-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 ± 2.1 pg/mL vs. 8.9 ± 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to slightly increase during the first 24 hr but significantly decline at the 7th day to levels (8.01 ± 1.7 pg/mL) which do not differ from those of controls. This study highlights a different alteration of plasma ET-1 in patients with β-thalassemia compared to that of patients with sickle-cell anemia.

KW - Hb E disease

KW - Plasma endothelin-1

KW - Transfusion

KW - β-thalassemia

UR - https://www.scopus.com/pages/publications/0036089573

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DO - 10.1002/ajh.10129

M3 - Article

C2 - 12118430

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SN - 0361-8609

VL - 70

SP - 260

EP - 262

JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 3

ER -

Baseline levels of plasma endothelin-1 (ET-1) and changes during transfusion in thalassemic patients

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Keywords

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