Asymptomatic Histoplasma Pylephlebitis in an Orthotopic Liver Transplant Recipient: A Case Report and Literature Review

Pakpoom Phoompoung; Methee Chayakulkeeree; Popchai Ngamskulrungroj; Ananya Pongpaibul

doi:10.1007/s11046-018-0265-6

Asymptomatic Histoplasma Pylephlebitis in an Orthotopic Liver Transplant Recipient: A Case Report and Literature Review

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

Histoplasma capsulatum is one of the most common pathogenic dimorphic fungi in Thailand. Its usual clinical syndrome is progressive disseminated histoplasmosis, whereas isolated hepatic histoplasmosis is extremely rare. Here, we report the world’s first reported case of hepatic histoplasmosis with pylephlebitis in a 45-year-old Thai male who underwent orthotopic liver transplantation due to hepatitis B cirrhosis. Histopathology of the recipient’s liver showed infiltration of fungal organisms in portal vein and hepatic granulomas. Serum H. capsulatum antibody was positive, and molecular identification from the liver revealed the DNA of H. capsulatum.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Mycopathologia
Volume	184
Issue number	1
DOIs	https://doi.org/10.1007/s11046-018-0265-6
Publication status	Published - 15 Feb 2019

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Histoplasma capsulatum
Histoplasmosis
Liver transplant
Pylephlebitis

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10.1007/s11046-018-0265-6

Cite this

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title = "Asymptomatic Histoplasma Pylephlebitis in an Orthotopic Liver Transplant Recipient: A Case Report and Literature Review",

abstract = "Histoplasma capsulatum is one of the most common pathogenic dimorphic fungi in Thailand. Its usual clinical syndrome is progressive disseminated histoplasmosis, whereas isolated hepatic histoplasmosis is extremely rare. Here, we report the world{\textquoteright}s first reported case of hepatic histoplasmosis with pylephlebitis in a 45-year-old Thai male who underwent orthotopic liver transplantation due to hepatitis B cirrhosis. Histopathology of the recipient{\textquoteright}s liver showed infiltration of fungal organisms in portal vein and hepatic granulomas. Serum H. capsulatum antibody was positive, and molecular identification from the liver revealed the DNA of H. capsulatum.",

keywords = "Histoplasma capsulatum, Histoplasmosis, Liver transplant, Pylephlebitis",

author = "Pakpoom Phoompoung and Methee Chayakulkeeree and Popchai Ngamskulrungroj and Ananya Pongpaibul",

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T1 - Asymptomatic Histoplasma Pylephlebitis in an Orthotopic Liver Transplant Recipient

T2 - A Case Report and Literature Review

AU - Phoompoung, Pakpoom

AU - Chayakulkeeree, Methee

AU - Ngamskulrungroj, Popchai

AU - Pongpaibul, Ananya

PY - 2019/2/15

Y1 - 2019/2/15

N2 - Histoplasma capsulatum is one of the most common pathogenic dimorphic fungi in Thailand. Its usual clinical syndrome is progressive disseminated histoplasmosis, whereas isolated hepatic histoplasmosis is extremely rare. Here, we report the world’s first reported case of hepatic histoplasmosis with pylephlebitis in a 45-year-old Thai male who underwent orthotopic liver transplantation due to hepatitis B cirrhosis. Histopathology of the recipient’s liver showed infiltration of fungal organisms in portal vein and hepatic granulomas. Serum H. capsulatum antibody was positive, and molecular identification from the liver revealed the DNA of H. capsulatum.

AB - Histoplasma capsulatum is one of the most common pathogenic dimorphic fungi in Thailand. Its usual clinical syndrome is progressive disseminated histoplasmosis, whereas isolated hepatic histoplasmosis is extremely rare. Here, we report the world’s first reported case of hepatic histoplasmosis with pylephlebitis in a 45-year-old Thai male who underwent orthotopic liver transplantation due to hepatitis B cirrhosis. Histopathology of the recipient’s liver showed infiltration of fungal organisms in portal vein and hepatic granulomas. Serum H. capsulatum antibody was positive, and molecular identification from the liver revealed the DNA of H. capsulatum.

KW - Histoplasma capsulatum

KW - Histoplasmosis

KW - Liver transplant

KW - Pylephlebitis

UR - https://www.scopus.com/pages/publications/85061268163

U2 - 10.1007/s11046-018-0265-6

DO - 10.1007/s11046-018-0265-6

M3 - Review article

C2 - 29789991

AN - SCOPUS:85061268163

SN - 0301-486X

VL - 184

SP - 177

EP - 180

JO - Mycopathologia

JF - Mycopathologia

IS - 1

ER -

Asymptomatic Histoplasma Pylephlebitis in an Orthotopic Liver Transplant Recipient: A Case Report and Literature Review

Abstract

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Keywords

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