Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum

Damrongkiet Arthan; Jisnuson Svasti; Prasat Kittakoop; Daraporn Pittayakhachonwut; Morakot Tanticharoen; Yodhathai Thebtaranonth

doi:10.1016/S0031-9422(01)00417-4

Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum

Damrongkiet Arthan
, Jisnuson Svasti
, Prasat Kittakoop
, Daraporn Pittayakhachonwut
, Morakot Tanticharoen
, Yodhathai Thebtaranonth

Mahidol University
National Science and Technology Development Agency (NSTDA)

Research output: Contribution to journal › Article › peer-review

198 Citations (Scopus)

Abstract

The C-4 sulfated isoflavonoid, torvanol A (1), and the steroidal glycoside, torvoside H (3), together with the known glycoside, torvoside A (2), were isolated from a MeOH extract of Solanum torvum fruits. Upon enzymatic hydrolysis with β-glucosidase, torvoside A (2) and torvoside H (3) yielded the corresponding acetal derivatives 4 and 5, respectively. Torvanol A (1), torvoside H (3) and compound 5 exhibited antiviral activity (herpes simplex virus type 1) with IC₅₀ values of 9.6, 23.2 and 17.4 μg/ml, respectively. Compounds 1-5 showed no cytotoxicity (at 50 μg/ml) against BC, KB and Vero cell lines.

Original language	English
Pages (from-to)	459-463
Number of pages	5
Journal	Phytochemistry
Volume	59
Issue number	4
DOIs	https://doi.org/10.1016/S0031-9422(01)00417-4
Publication status	Published - 26 Feb 2002
Externally published	Yes

Keywords

Antiviral compounds
Herpes simplex virus
Isoflavonoid
Solanaceae
Solanum torvum
Steroidal glycoside

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10.1016/S0031-9422(01)00417-4

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title = "Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum",

abstract = "The C-4 sulfated isoflavonoid, torvanol A (1), and the steroidal glycoside, torvoside H (3), together with the known glycoside, torvoside A (2), were isolated from a MeOH extract of Solanum torvum fruits. Upon enzymatic hydrolysis with β-glucosidase, torvoside A (2) and torvoside H (3) yielded the corresponding acetal derivatives 4 and 5, respectively. Torvanol A (1), torvoside H (3) and compound 5 exhibited antiviral activity (herpes simplex virus type 1) with IC50 values of 9.6, 23.2 and 17.4 μg/ml, respectively. Compounds 1-5 showed no cytotoxicity (at 50 μg/ml) against BC, KB and Vero cell lines.",

keywords = "Antiviral compounds, Herpes simplex virus, Isoflavonoid, Solanaceae, Solanum torvum, Steroidal glycoside",

author = "Damrongkiet Arthan and Jisnuson Svasti and Prasat Kittakoop and Daraporn Pittayakhachonwut and Morakot Tanticharoen and Yodhathai Thebtaranonth",

year = "2002",

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doi = "10.1016/S0031-9422(01)00417-4",

language = "English",

volume = "59",

pages = "459--463",

journal = "Phytochemistry",

issn = "0031-9422",

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TY - JOUR

T1 - Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum

AU - Arthan, Damrongkiet

AU - Svasti, Jisnuson

AU - Kittakoop, Prasat

AU - Pittayakhachonwut, Daraporn

AU - Tanticharoen, Morakot

AU - Thebtaranonth, Yodhathai

PY - 2002/2/26

Y1 - 2002/2/26

N2 - The C-4 sulfated isoflavonoid, torvanol A (1), and the steroidal glycoside, torvoside H (3), together with the known glycoside, torvoside A (2), were isolated from a MeOH extract of Solanum torvum fruits. Upon enzymatic hydrolysis with β-glucosidase, torvoside A (2) and torvoside H (3) yielded the corresponding acetal derivatives 4 and 5, respectively. Torvanol A (1), torvoside H (3) and compound 5 exhibited antiviral activity (herpes simplex virus type 1) with IC50 values of 9.6, 23.2 and 17.4 μg/ml, respectively. Compounds 1-5 showed no cytotoxicity (at 50 μg/ml) against BC, KB and Vero cell lines.

AB - The C-4 sulfated isoflavonoid, torvanol A (1), and the steroidal glycoside, torvoside H (3), together with the known glycoside, torvoside A (2), were isolated from a MeOH extract of Solanum torvum fruits. Upon enzymatic hydrolysis with β-glucosidase, torvoside A (2) and torvoside H (3) yielded the corresponding acetal derivatives 4 and 5, respectively. Torvanol A (1), torvoside H (3) and compound 5 exhibited antiviral activity (herpes simplex virus type 1) with IC50 values of 9.6, 23.2 and 17.4 μg/ml, respectively. Compounds 1-5 showed no cytotoxicity (at 50 μg/ml) against BC, KB and Vero cell lines.

KW - Antiviral compounds

KW - Herpes simplex virus

KW - Isoflavonoid

KW - Solanaceae

KW - Solanum torvum

KW - Steroidal glycoside

UR - https://www.scopus.com/pages/publications/0037176744

U2 - 10.1016/S0031-9422(01)00417-4

DO - 10.1016/S0031-9422(01)00417-4

M3 - Article

C2 - 11830167

AN - SCOPUS:0037176744

SN - 0031-9422

VL - 59

SP - 459

EP - 463

JO - Phytochemistry

JF - Phytochemistry

IS - 4

ER -

Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum

Abstract

Keywords

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