Antiparasitic chaiyaphumines from entomopathogenic xenorhabdus sp. PB61.4

Florian Grundmann; Marcel Kaiser; Matthias Schiell; Andreas Batzer; Michael Kurz; Aunchalee Thanwisai; Narisara Chantratita; Helge B. Bode

doi:10.1021/np4007525

Antiparasitic chaiyaphumines from entomopathogenic xenorhabdus sp. PB61.4

Florian Grundmann
, Marcel Kaiser
, Matthias Schiell
, Andreas Batzer
, Michael Kurz
, Aunchalee Thanwisai
, Narisara Chantratita
, Helge B. Bode

Department of Microbiology and Immunology

Johann Wolfgang Goethe University
Swiss Tropical and Public Health Institute, Parasite Chemotherapy
Sanofi-Aventis Deutschland GmbH
Naresuan University

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

A new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfeys analysis following flash hydrolysis of the peptide. Verification of the structure was achieved by three-dimensional modeling using NOE-derived distance constraints, molecular dynamics, and energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC₅₀ of 0.61 μM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents.

Original language	English
Pages (from-to)	779-783
Number of pages	5
Journal	Journal of Natural Products
Volume	77
Issue number	4
DOIs	https://doi.org/10.1021/np4007525
Publication status	Published - 25 Apr 2014

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title = "Antiparasitic chaiyaphumines from entomopathogenic xenorhabdus sp. PB61.4",

abstract = "A new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfeys analysis following flash hydrolysis of the peptide. Verification of the structure was achieved by three-dimensional modeling using NOE-derived distance constraints, molecular dynamics, and energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 μM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents.",

author = "Florian Grundmann and Marcel Kaiser and Matthias Schiell and Andreas Batzer and Michael Kurz and Aunchalee Thanwisai and Narisara Chantratita and Bode, \{Helge B.\}",

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AU - Grundmann, Florian

AU - Kaiser, Marcel

AU - Schiell, Matthias

AU - Batzer, Andreas

AU - Kurz, Michael

AU - Thanwisai, Aunchalee

AU - Chantratita, Narisara

AU - Bode, Helge B.

PY - 2014/4/25

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N2 - A new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfeys analysis following flash hydrolysis of the peptide. Verification of the structure was achieved by three-dimensional modeling using NOE-derived distance constraints, molecular dynamics, and energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 μM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents.

AB - A new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfeys analysis following flash hydrolysis of the peptide. Verification of the structure was achieved by three-dimensional modeling using NOE-derived distance constraints, molecular dynamics, and energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 μM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Antiparasitic chaiyaphumines from entomopathogenic xenorhabdus sp. PB61.4

Abstract

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