Antimalarial activity and cytotoxicity of zerumbone derivatives

Uraiwan Sriphana; Siripit Pitchuanchom; Palangpon Kongsaeree; Chavi Yenjai

doi:10.2306/scienceasia1513-1874.2013.39.095

Antimalarial activity and cytotoxicity of zerumbone derivatives

Uraiwan Sriphana
, Siripit Pitchuanchom
, Palangpon Kongsaeree
, Chavi Yenjai

Khon Kaen University
Mahidol University

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Zerumbone, a sesquiterpene isolated from the rhizome of Zingiber zerumbet, shows strong antimalarial and cytotoxic activities. A series of zerumbone derivatives were synthesized and evaluated for in vitro antimalarial activity against Plasmodium falciparum and cytotoxicity against human cancer cell lines (NCI-H187, KB and BC) as well as normal cells (Vero cells). Three of the compounds showed potent antimalarial activity with IC₅₀ values of 32.8, 13.7, and 9.8 μM. They were less toxic against Vero cells.

Original language	English
Pages (from-to)	95-99
Number of pages	5
Journal	ScienceAsia
Volume	39
Issue number	1
DOIs	https://doi.org/10.2306/scienceasia1513-1874.2013.39.095
Publication status	Published - Mar 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cyanozerumbone
Plasmodium falciparum
Sesquiterpene
Zingiber zerumbet

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10.2306/scienceasia1513-1874.2013.39.095

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title = "Antimalarial activity and cytotoxicity of zerumbone derivatives",

abstract = "Zerumbone, a sesquiterpene isolated from the rhizome of Zingiber zerumbet, shows strong antimalarial and cytotoxic activities. A series of zerumbone derivatives were synthesized and evaluated for in vitro antimalarial activity against Plasmodium falciparum and cytotoxicity against human cancer cell lines (NCI-H187, KB and BC) as well as normal cells (Vero cells). Three of the compounds showed potent antimalarial activity with IC50 values of 32.8, 13.7, and 9.8 μM. They were less toxic against Vero cells.",

keywords = "Cyanozerumbone, Plasmodium falciparum, Sesquiterpene, Zingiber zerumbet",

author = "Uraiwan Sriphana and Siripit Pitchuanchom and Palangpon Kongsaeree and Chavi Yenjai",

year = "2013",

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pages = "95--99",

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T1 - Antimalarial activity and cytotoxicity of zerumbone derivatives

AU - Sriphana, Uraiwan

AU - Pitchuanchom, Siripit

AU - Kongsaeree, Palangpon

AU - Yenjai, Chavi

PY - 2013/3

Y1 - 2013/3

N2 - Zerumbone, a sesquiterpene isolated from the rhizome of Zingiber zerumbet, shows strong antimalarial and cytotoxic activities. A series of zerumbone derivatives were synthesized and evaluated for in vitro antimalarial activity against Plasmodium falciparum and cytotoxicity against human cancer cell lines (NCI-H187, KB and BC) as well as normal cells (Vero cells). Three of the compounds showed potent antimalarial activity with IC50 values of 32.8, 13.7, and 9.8 μM. They were less toxic against Vero cells.

AB - Zerumbone, a sesquiterpene isolated from the rhizome of Zingiber zerumbet, shows strong antimalarial and cytotoxic activities. A series of zerumbone derivatives were synthesized and evaluated for in vitro antimalarial activity against Plasmodium falciparum and cytotoxicity against human cancer cell lines (NCI-H187, KB and BC) as well as normal cells (Vero cells). Three of the compounds showed potent antimalarial activity with IC50 values of 32.8, 13.7, and 9.8 μM. They were less toxic against Vero cells.

KW - Cyanozerumbone

KW - Plasmodium falciparum

KW - Sesquiterpene

KW - Zingiber zerumbet

UR - https://www.scopus.com/pages/publications/84874839836

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DO - 10.2306/scienceasia1513-1874.2013.39.095

M3 - Article

AN - SCOPUS:84874839836

SN - 1513-1874

VL - 39

SP - 95

EP - 99

JO - ScienceAsia

JF - ScienceAsia

IS - 1

ER -

Antimalarial activity and cytotoxicity of zerumbone derivatives

Abstract

UN SDGs

Keywords

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