Anticancer activities of antimicrobial BmKn2 peptides against oral and colon cancer cells

Teerakul Arpornsuwan; Wimolpak Sriwai; Janthima Jaresitthikunchai; Narumon Phaonakrop; Hathaitip Sritanaudomchai; Sittiruk Roytrakul

doi:10.1007/s10989-014-9417-9

Anticancer activities of antimicrobial BmKn2 peptides against oral and colon cancer cells

Teerakul Arpornsuwan
, Wimolpak Sriwai
, Janthima Jaresitthikunchai
, Narumon Phaonakrop
, Hathaitip Sritanaudomchai
, Sittiruk Roytrakul

Department of Oral Biology

Faculty of Allied Health Sciences Thammasat University
National Science and Technology Development Agency (NSTDA)

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

There is considerable current interest in developing antimicrobial and anticancer agents with a new mode of action. The antimicrobial peptides are regarded as a potential solution for treating cancer cells. The antimicrobial effect of 6 synthetic peptides against 7 bacterial species was evaluated. The result showed that IsCT, BmKn2 and BMAP-28 exhibited broad range of action against Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538, methicillin resistant S. aureus DMST 20651, Staphylococcus epidermidis ATCC 12228, Acinetobacter baumanii ATCC 19066, Escherichia coli ATCC 25922 and Salmonella typhi DMST 562 at minimal inhibitory concentrations (MIC) of 2.97-24.28 μM. Neither AMP induced significant hemolysis, or showed cytotoxic on dental pulp stem cells and smooth muscle cells at their MICs. In addition, BmKn2 inhibited growth of human oral squamous carcinoma HSC4 cells and human colon cancer SW620 cells with IC₅₀ of 17.26 and 40 μM, respectively. Taken together, BmKn2 peptide from scorpion venom may offer a novel therapeutic strategy for development of cationic antimicrobial and anticancer peptides as potential new therapeutic agents.

Original language	English
Pages (from-to)	501-509
Number of pages	9
Journal	International Journal of Peptide Research and Therapeutics
Volume	20
Issue number	4
DOIs	https://doi.org/10.1007/s10989-014-9417-9
Publication status	Published - Dec 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimicrobial peptide
Antitumor peptide
Dental pulp stem cells
HSC4 cells
SW620 cells

Access to Document

10.1007/s10989-014-9417-9

Cite this

@article{64a4a2b170dd45b3ac70ebc43b3248a6,

title = "Anticancer activities of antimicrobial BmKn2 peptides against oral and colon cancer cells",

abstract = "There is considerable current interest in developing antimicrobial and anticancer agents with a new mode of action. The antimicrobial peptides are regarded as a potential solution for treating cancer cells. The antimicrobial effect of 6 synthetic peptides against 7 bacterial species was evaluated. The result showed that IsCT, BmKn2 and BMAP-28 exhibited broad range of action against Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538, methicillin resistant S. aureus DMST 20651, Staphylococcus epidermidis ATCC 12228, Acinetobacter baumanii ATCC 19066, Escherichia coli ATCC 25922 and Salmonella typhi DMST 562 at minimal inhibitory concentrations (MIC) of 2.97-24.28 μM. Neither AMP induced significant hemolysis, or showed cytotoxic on dental pulp stem cells and smooth muscle cells at their MICs. In addition, BmKn2 inhibited growth of human oral squamous carcinoma HSC4 cells and human colon cancer SW620 cells with IC50 of 17.26 and 40 μM, respectively. Taken together, BmKn2 peptide from scorpion venom may offer a novel therapeutic strategy for development of cationic antimicrobial and anticancer peptides as potential new therapeutic agents.",

keywords = "Antimicrobial peptide, Antitumor peptide, Dental pulp stem cells, HSC4 cells, SW620 cells",

author = "Teerakul Arpornsuwan and Wimolpak Sriwai and Janthima Jaresitthikunchai and Narumon Phaonakrop and Hathaitip Sritanaudomchai and Sittiruk Roytrakul",

note = "Publisher Copyright: {\textcopyright} 2014 Springer Science+Business Media New York.",

year = "2014",

month = dec,

doi = "10.1007/s10989-014-9417-9",

language = "English",

volume = "20",

pages = "501--509",

journal = "International Journal of Peptide Research and Therapeutics",

issn = "1573-3149",

publisher = "Springer Science and Business Media B.V.",

number = "4",

}

TY - JOUR

T1 - Anticancer activities of antimicrobial BmKn2 peptides against oral and colon cancer cells

AU - Arpornsuwan, Teerakul

AU - Sriwai, Wimolpak

AU - Jaresitthikunchai, Janthima

AU - Phaonakrop, Narumon

AU - Sritanaudomchai, Hathaitip

AU - Roytrakul, Sittiruk

PY - 2014/12

Y1 - 2014/12

N2 - There is considerable current interest in developing antimicrobial and anticancer agents with a new mode of action. The antimicrobial peptides are regarded as a potential solution for treating cancer cells. The antimicrobial effect of 6 synthetic peptides against 7 bacterial species was evaluated. The result showed that IsCT, BmKn2 and BMAP-28 exhibited broad range of action against Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538, methicillin resistant S. aureus DMST 20651, Staphylococcus epidermidis ATCC 12228, Acinetobacter baumanii ATCC 19066, Escherichia coli ATCC 25922 and Salmonella typhi DMST 562 at minimal inhibitory concentrations (MIC) of 2.97-24.28 μM. Neither AMP induced significant hemolysis, or showed cytotoxic on dental pulp stem cells and smooth muscle cells at their MICs. In addition, BmKn2 inhibited growth of human oral squamous carcinoma HSC4 cells and human colon cancer SW620 cells with IC50 of 17.26 and 40 μM, respectively. Taken together, BmKn2 peptide from scorpion venom may offer a novel therapeutic strategy for development of cationic antimicrobial and anticancer peptides as potential new therapeutic agents.

AB - There is considerable current interest in developing antimicrobial and anticancer agents with a new mode of action. The antimicrobial peptides are regarded as a potential solution for treating cancer cells. The antimicrobial effect of 6 synthetic peptides against 7 bacterial species was evaluated. The result showed that IsCT, BmKn2 and BMAP-28 exhibited broad range of action against Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538, methicillin resistant S. aureus DMST 20651, Staphylococcus epidermidis ATCC 12228, Acinetobacter baumanii ATCC 19066, Escherichia coli ATCC 25922 and Salmonella typhi DMST 562 at minimal inhibitory concentrations (MIC) of 2.97-24.28 μM. Neither AMP induced significant hemolysis, or showed cytotoxic on dental pulp stem cells and smooth muscle cells at their MICs. In addition, BmKn2 inhibited growth of human oral squamous carcinoma HSC4 cells and human colon cancer SW620 cells with IC50 of 17.26 and 40 μM, respectively. Taken together, BmKn2 peptide from scorpion venom may offer a novel therapeutic strategy for development of cationic antimicrobial and anticancer peptides as potential new therapeutic agents.

KW - Antimicrobial peptide

KW - Antitumor peptide

KW - Dental pulp stem cells

KW - HSC4 cells

KW - SW620 cells

UR - https://www.scopus.com/pages/publications/84939890005

U2 - 10.1007/s10989-014-9417-9

DO - 10.1007/s10989-014-9417-9

M3 - Article

AN - SCOPUS:84939890005

SN - 1573-3149

VL - 20

SP - 501

EP - 509

JO - International Journal of Peptide Research and Therapeutics

JF - International Journal of Peptide Research and Therapeutics

IS - 4

ER -

Anticancer activities of antimicrobial BmKn2 peptides against oral and colon cancer cells

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this