An antimalarial stilbene from Artocarpus integer

Choosak Boonlaksiri; Worrapoj Oonanant; Palangpon Kongsaeree; Prasat Kittakoop; Morakot Tanticharoen; Yodhathai Thebtaranonth

doi:10.1016/S0031-9422(00)00074-1

An antimalarial stilbene from Artocarpus integer

Choosak Boonlaksiri
, Worrapoj Oonanant
, Palangpon Kongsaeree
, Prasat Kittakoop
, Morakot Tanticharoen
, Yodhathai Thebtaranonth

Mahidol University
National Science and Technology Development Agency (NSTDA)

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

Abstract

Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E- but-1-enyl)-3,5,2',4'- tetrahydroxystilbene with an EC₅₀ of 1.7 μg/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4- isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2- (2,4-dihydroxy)phenyl-trans-ethenyl)chromene, were also isolated. Structures of these compounds were deduced on the basis of their spectral data. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	415-417
Number of pages	3
Journal	Phytochemistry
Volume	54
Issue number	4
DOIs	https://doi.org/10.1016/S0031-9422(00)00074-1
Publication status	Published - 1 Jun 2000
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3,5,2',4'- Tetrahydroxystilbene
Antimalarial activity
Artocarpus integer
Jumpada
Moraceae
Plasmodium falciparum

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10.1016/S0031-9422(00)00074-1

Cite this

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title = "An antimalarial stilbene from Artocarpus integer",

abstract = "Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E- but-1-enyl)-3,5,2',4'- tetrahydroxystilbene with an EC50 of 1.7 μg/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4- isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2- (2,4-dihydroxy)phenyl-trans-ethenyl)chromene, were also isolated. Structures of these compounds were deduced on the basis of their spectral data. (C) 2000 Elsevier Science Ltd.",

keywords = "3,5,2',4'- Tetrahydroxystilbene, Antimalarial activity, Artocarpus integer, Jumpada, Moraceae, Plasmodium falciparum",

author = "Choosak Boonlaksiri and Worrapoj Oonanant and Palangpon Kongsaeree and Prasat Kittakoop and Morakot Tanticharoen and Yodhathai Thebtaranonth",

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doi = "10.1016/S0031-9422(00)00074-1",

language = "English",

volume = "54",

pages = "415--417",

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T1 - An antimalarial stilbene from Artocarpus integer

AU - Boonlaksiri, Choosak

AU - Oonanant, Worrapoj

AU - Kongsaeree, Palangpon

AU - Kittakoop, Prasat

AU - Tanticharoen, Morakot

AU - Thebtaranonth, Yodhathai

PY - 2000/6/1

Y1 - 2000/6/1

N2 - Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E- but-1-enyl)-3,5,2',4'- tetrahydroxystilbene with an EC50 of 1.7 μg/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4- isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2- (2,4-dihydroxy)phenyl-trans-ethenyl)chromene, were also isolated. Structures of these compounds were deduced on the basis of their spectral data. (C) 2000 Elsevier Science Ltd.

AB - Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E- but-1-enyl)-3,5,2',4'- tetrahydroxystilbene with an EC50 of 1.7 μg/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4- isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2- (2,4-dihydroxy)phenyl-trans-ethenyl)chromene, were also isolated. Structures of these compounds were deduced on the basis of their spectral data. (C) 2000 Elsevier Science Ltd.

KW - 3,5,2',4'- Tetrahydroxystilbene

KW - Antimalarial activity

KW - Artocarpus integer

KW - Jumpada

KW - Moraceae

KW - Plasmodium falciparum

UR - https://www.scopus.com/pages/publications/0034733502

U2 - 10.1016/S0031-9422(00)00074-1

DO - 10.1016/S0031-9422(00)00074-1

M3 - Article

C2 - 10897483

AN - SCOPUS:0034733502

SN - 0031-9422

VL - 54

SP - 415

EP - 417

JO - Phytochemistry

JF - Phytochemistry

IS - 4

ER -

An antimalarial stilbene from Artocarpus integer

Abstract

UN SDGs

Keywords

Access to Document

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