Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression

Kanokwan Kittiniyom; Karen M. Gorse; Fabienne Dalbegue; Jack H. Lichy; Jeffery K. Taubenberger; Irene F. Newsham

doi:10.1186/bcr294

Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression

Kanokwan Kittiniyom
, Karen M. Gorse
, Fabienne Dalbegue
, Jack H. Lichy
, Jeffery K. Taubenberger
, Irene F. Newsham

Department of Pathology
Virginia Commonwealth University
Armed Forces Institute of Pathology

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

Original language	English
Pages (from-to)	192-198
Number of pages	7
Journal	Breast Cancer Research
Volume	3
Issue number	3
DOIs	https://doi.org/10.1186/bcr294
Publication status	Published - 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

18p
Breast cancer
Heterogeneity
Loss of heterozygosity
Progression

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10.1186/bcr294

Cite this

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title = "Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression",

abstract = "We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63\%) was found, with 56\% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27\% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.",

keywords = "18p, Breast cancer, Heterogeneity, Loss of heterozygosity, Progression",

author = "Kanokwan Kittiniyom and Gorse, \{Karen M.\} and Fabienne Dalbegue and Lichy, \{Jack H.\} and Taubenberger, \{Jeffery K.\} and Newsham, \{Irene F.\}",

year = "2001",

doi = "10.1186/bcr294",

language = "English",

volume = "3",

pages = "192--198",

journal = "Breast Cancer Research",

issn = "1465-5411",

publisher = "BioMed Central Ltd.",

number = "3",

}

TY - JOUR

T1 - Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression

AU - Kittiniyom, Kanokwan

AU - Gorse, Karen M.

AU - Dalbegue, Fabienne

AU - Lichy, Jack H.

AU - Taubenberger, Jeffery K.

AU - Newsham, Irene F.

PY - 2001

Y1 - 2001

N2 - We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

AB - We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

KW - 18p

KW - Breast cancer

KW - Heterogeneity

KW - Loss of heterozygosity

KW - Progression

UR - https://www.scopus.com/pages/publications/0035028023

U2 - 10.1186/bcr294

DO - 10.1186/bcr294

M3 - Article

C2 - 11305954

AN - SCOPUS:0035028023

SN - 1465-5411

VL - 3

SP - 192

EP - 198

JO - Breast Cancer Research

JF - Breast Cancer Research

IS - 3

ER -

Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression

Abstract

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Keywords

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