Aigialomycins and related polyketide metabolites from the mangrove fungus Aigialus parvus BCC 5311

Masahiko Isaka; Arunrat Yangchum; Sutichai Intamas; Kanokarn Kocharin; E. B.Gareth Jones; Palangpon Kongsaeree; Samran Prabpai

doi:10.1016/j.tet.2009.03.050

Aigialomycins and related polyketide metabolites from the mangrove fungus Aigialus parvus BCC 5311

Masahiko Isaka
, Arunrat Yangchum
, Sutichai Intamas
, Kanokarn Kocharin
, E. B.Gareth Jones
, Palangpon Kongsaeree
, Samran Prabpai

National Science and Technology Development Agency (NSTDA)
Mahidol University

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Reinvestigation of the secondary metabolites from the marine mangrove fungus Aigialus parvus BCC 5311 led to the isolation of six new nonaketide metabolites, aigialomycins F (4) and G (5a/5b), 7′,8′-dihydroaigialospirol (7), 4′-deoxy-7′,8′-dihydroaigialospirol (8), and rearranged macrolides 9 and 10, along with six previously described compounds, hypothemycin (1), aigialomycins A (2) and B (3), aigialospirol (6), 4-O-demethylhypothemycin (11), and aigialone (12). The structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data in combination with chemical means.

Original language	English
Pages (from-to)	4396-4403
Number of pages	8
Journal	Tetrahedron
Volume	65
Issue number	22
DOIs	https://doi.org/10.1016/j.tet.2009.03.050
Publication status	Published - 30 May 2009
Externally published	Yes

Keywords

Aigialomycin
Aigialospirol
Aigialus parvus
Marine fungi
Resorcylic acid lactone

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10.1016/j.tet.2009.03.050

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title = "Aigialomycins and related polyketide metabolites from the mangrove fungus Aigialus parvus BCC 5311",

abstract = "Reinvestigation of the secondary metabolites from the marine mangrove fungus Aigialus parvus BCC 5311 led to the isolation of six new nonaketide metabolites, aigialomycins F (4) and G (5a/5b), 7′,8′-dihydroaigialospirol (7), 4′-deoxy-7′,8′-dihydroaigialospirol (8), and rearranged macrolides 9 and 10, along with six previously described compounds, hypothemycin (1), aigialomycins A (2) and B (3), aigialospirol (6), 4-O-demethylhypothemycin (11), and aigialone (12). The structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data in combination with chemical means.",

keywords = "Aigialomycin, Aigialospirol, Aigialus parvus, Marine fungi, Resorcylic acid lactone",

author = "Masahiko Isaka and Arunrat Yangchum and Sutichai Intamas and Kanokarn Kocharin and Jones, \{E. B.Gareth\} and Palangpon Kongsaeree and Samran Prabpai",

year = "2009",

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doi = "10.1016/j.tet.2009.03.050",

language = "English",

volume = "65",

pages = "4396--4403",

journal = "Tetrahedron",

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T1 - Aigialomycins and related polyketide metabolites from the mangrove fungus Aigialus parvus BCC 5311

AU - Isaka, Masahiko

AU - Yangchum, Arunrat

AU - Intamas, Sutichai

AU - Kocharin, Kanokarn

AU - Jones, E. B.Gareth

AU - Kongsaeree, Palangpon

AU - Prabpai, Samran

PY - 2009/5/30

Y1 - 2009/5/30

N2 - Reinvestigation of the secondary metabolites from the marine mangrove fungus Aigialus parvus BCC 5311 led to the isolation of six new nonaketide metabolites, aigialomycins F (4) and G (5a/5b), 7′,8′-dihydroaigialospirol (7), 4′-deoxy-7′,8′-dihydroaigialospirol (8), and rearranged macrolides 9 and 10, along with six previously described compounds, hypothemycin (1), aigialomycins A (2) and B (3), aigialospirol (6), 4-O-demethylhypothemycin (11), and aigialone (12). The structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data in combination with chemical means.

AB - Reinvestigation of the secondary metabolites from the marine mangrove fungus Aigialus parvus BCC 5311 led to the isolation of six new nonaketide metabolites, aigialomycins F (4) and G (5a/5b), 7′,8′-dihydroaigialospirol (7), 4′-deoxy-7′,8′-dihydroaigialospirol (8), and rearranged macrolides 9 and 10, along with six previously described compounds, hypothemycin (1), aigialomycins A (2) and B (3), aigialospirol (6), 4-O-demethylhypothemycin (11), and aigialone (12). The structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data in combination with chemical means.

KW - Aigialomycin

KW - Aigialospirol

KW - Aigialus parvus

KW - Marine fungi

KW - Resorcylic acid lactone

UR - https://www.scopus.com/pages/publications/65349189541

U2 - 10.1016/j.tet.2009.03.050

DO - 10.1016/j.tet.2009.03.050

M3 - Article

AN - SCOPUS:65349189541

SN - 0040-4020

VL - 65

SP - 4396

EP - 4403

JO - Tetrahedron

JF - Tetrahedron

IS - 22

ER -

Aigialomycins and related polyketide metabolites from the mangrove fungus Aigialus parvus BCC 5311

Abstract

Keywords

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