Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus

Masahiko Isaka; Chotika Suyarnsestakorn; Morakot Tanticharoen; Palangpon Kongsaeree; Yodhathai Thebtaranonth

doi:10.1021/jo010930g

Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus

Masahiko Isaka
, Chotika Suyarnsestakorn
, Morakot Tanticharoen
, Palangpon Kongsaeree
, Yodhathai Thebtaranonth

National Science and Technology Development Agency (NSTDA)
Mahidol University

Research output: Contribution to journal › Article › peer-review

222 Citations (Scopus)

Abstract

Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC₅₀ values of 2.2 and 6.6 μg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.

Original language	English
Pages (from-to)	1561-1566
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	67
Issue number	5
DOIs	https://doi.org/10.1021/jo010930g
Publication status	Published - 8 Mar 2002
Externally published	Yes

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10.1021/jo010930g

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abstract = "Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC50 values of 2.2 and 6.6 μg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.",

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AU - Isaka, Masahiko

AU - Suyarnsestakorn, Chotika

AU - Tanticharoen, Morakot

AU - Kongsaeree, Palangpon

AU - Thebtaranonth, Yodhathai

PY - 2002/3/8

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AB - Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC50 values of 2.2 and 6.6 μg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.

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ER -

Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus

Abstract

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