A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly

Supakanya Wongrakpanich; Amaraporn Wongrakpanich; Katie Melhado; Janani Rangaswami

doi:10.14336/AD.2017.0306

A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly

Supakanya Wongrakpanich
, Amaraporn Wongrakpanich
, Katie Melhado
, Janani Rangaswami

Department of Pharmacy

Albert Einstein Medical Center

Research output: Contribution to journal › Review article › peer-review

794 Citations (Scopus)

Abstract

NSAIDs, non-steroidal anti-inflammatory drugs, are one of the most commonly prescribed pain medications. It is a highly effective drug class for pain and inflammation; however, NSAIDs are known for multiple adverse effects, including gastrointestinal bleeding, cardiovascular side effects, and NSAID induced nephrotoxicity. As our society ages, it is crucial to have comprehensive knowledge of this class of medication in the elderly population. Therefore, we reviewed the pharmacodynamics and pharmacokinetics, current guidelines for NSAIDs use, adverse effect profile, and drug interaction of NSAIDs and commonly used medications in the elderly.

Original language	English
Pages (from-to)	143-150
Number of pages	8
Journal	Aging and Disease
Volume	9
Issue number	1
DOIs	https://doi.org/10.14336/AD.2017.0306
Publication status	Published - 1 Feb 2018

Keywords

Elderly
Geriatric conditions
NSAIDs
Non-steroidal anti-inflammatory drug
Pleiotropic effects

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10.14336/AD.2017.0306

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title = "A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly",

abstract = "NSAIDs, non-steroidal anti-inflammatory drugs, are one of the most commonly prescribed pain medications. It is a highly effective drug class for pain and inflammation; however, NSAIDs are known for multiple adverse effects, including gastrointestinal bleeding, cardiovascular side effects, and NSAID induced nephrotoxicity. As our society ages, it is crucial to have comprehensive knowledge of this class of medication in the elderly population. Therefore, we reviewed the pharmacodynamics and pharmacokinetics, current guidelines for NSAIDs use, adverse effect profile, and drug interaction of NSAIDs and commonly used medications in the elderly.",

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AU - Melhado, Katie

AU - Rangaswami, Janani

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N2 - NSAIDs, non-steroidal anti-inflammatory drugs, are one of the most commonly prescribed pain medications. It is a highly effective drug class for pain and inflammation; however, NSAIDs are known for multiple adverse effects, including gastrointestinal bleeding, cardiovascular side effects, and NSAID induced nephrotoxicity. As our society ages, it is crucial to have comprehensive knowledge of this class of medication in the elderly population. Therefore, we reviewed the pharmacodynamics and pharmacokinetics, current guidelines for NSAIDs use, adverse effect profile, and drug interaction of NSAIDs and commonly used medications in the elderly.

AB - NSAIDs, non-steroidal anti-inflammatory drugs, are one of the most commonly prescribed pain medications. It is a highly effective drug class for pain and inflammation; however, NSAIDs are known for multiple adverse effects, including gastrointestinal bleeding, cardiovascular side effects, and NSAID induced nephrotoxicity. As our society ages, it is crucial to have comprehensive knowledge of this class of medication in the elderly population. Therefore, we reviewed the pharmacodynamics and pharmacokinetics, current guidelines for NSAIDs use, adverse effect profile, and drug interaction of NSAIDs and commonly used medications in the elderly.

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KW - Non-steroidal anti-inflammatory drug

KW - Pleiotropic effects

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JO - Aging and Disease

JF - Aging and Disease

IS - 1

ER -

A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly

Abstract

Keywords

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