A comparison of propofol-LCT with propofol-LCT/MCT on pain of injection

Background: Propofol-Lipuro 1% is consisting of long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) that have been reported to reduce injection pain. Objective: To compare the incidence and intensity of injection pain with 1% Propofol-LCT with 1% Propofol-LCT/MCT in female populations for minor surgery under total intravenous anesthesia (TIVA). Material and Method: One hundred and ten female patients were double-blind randomized into two groups. Group long-chain triglycerdes (L) received 1% propofol-LCT while group long-chain triglycerides/mediumchain triglycerides (L/M) received 1% propofol-LCT/MCT. All patients received no benzodiazepine premedication and fentanyl 1 μg/kg was given 3 minutes before propofol injection. The propofol 1 mg/kg was manually injected at 0.5 mL/sec. The verbal rating score (VRS 0-10) was recorded on pain of injection. VRS > 4 indicates a significant response to pain. Results: There was a significantly greater incidence and intensity of injection pain in group L compared with group L/M (p < 0.001 and p = 0.013 respectively). Conclusions: Propofol-LCT/MCT is superior to propofol-LCT on reducing pain of injection.