6,7,14,15-Tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole. Synthesis of a novel pentacyclic ring system

Kittisak Sripha; Darius Paul Zlotos

doi:10.1016/S0040-4020(02)01530-2

6,7,14,15-Tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole. Synthesis of a novel pentacyclic ring system

Kittisak Sripha
, Darius Paul Zlotos

Universität Würzburg

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M₂ receptors, the first representative of a novel heterocyclic ring system, 6,7,14,15-tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole, has been synthesized. The new pentacyclic ring skeleton is obtained from [3-(2-dibenzylaminoethyl)indol-2-yl]-acetic acid methyl ester in three steps.

Original language	English
Pages (from-to)	391-394
Number of pages	4
Journal	Tetrahedron
Volume	59
Issue number	3
DOIs	https://doi.org/10.1016/S0040-4020(02)01530-2
Publication status	Published - 13 Jan 2003
Externally published	Yes

Keywords

6,7,14,15-tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole
Dimerization of bromoethylindole
Muscarinic active compounds
Novel pentacyclic ring system

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10.1016/S0040-4020(02)01530-2

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title = "6,7,14,15-Tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole. Synthesis of a novel pentacyclic ring system",

abstract = "In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M2 receptors, the first representative of a novel heterocyclic ring system, 6,7,14,15-tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole, has been synthesized. The new pentacyclic ring skeleton is obtained from [3-(2-dibenzylaminoethyl)indol-2-yl]-acetic acid methyl ester in three steps.",

keywords = "6,7,14,15-tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole, Dimerization of bromoethylindole, Muscarinic active compounds, Novel pentacyclic ring system",

author = "Kittisak Sripha and Zlotos, \{Darius Paul\}",

year = "2003",

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doi = "10.1016/S0040-4020(02)01530-2",

language = "English",

volume = "59",

pages = "391--394",

journal = "Tetrahedron",

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number = "3",

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T1 - 6,7,14,15-Tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole. Synthesis of a novel pentacyclic ring system

AU - Sripha, Kittisak

AU - Zlotos, Darius Paul

PY - 2003/1/13

Y1 - 2003/1/13

N2 - In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M2 receptors, the first representative of a novel heterocyclic ring system, 6,7,14,15-tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole, has been synthesized. The new pentacyclic ring skeleton is obtained from [3-(2-dibenzylaminoethyl)indol-2-yl]-acetic acid methyl ester in three steps.

AB - In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M2 receptors, the first representative of a novel heterocyclic ring system, 6,7,14,15-tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole, has been synthesized. The new pentacyclic ring skeleton is obtained from [3-(2-dibenzylaminoethyl)indol-2-yl]-acetic acid methyl ester in three steps.

KW - 6,7,14,15-tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole

KW - Dimerization of bromoethylindole

KW - Muscarinic active compounds

KW - Novel pentacyclic ring system

UR - https://www.scopus.com/pages/publications/0037434037

U2 - 10.1016/S0040-4020(02)01530-2

DO - 10.1016/S0040-4020(02)01530-2

M3 - Article

AN - SCOPUS:0037434037

SN - 0040-4020

VL - 59

SP - 391

EP - 394

JO - Tetrahedron

JF - Tetrahedron

IS - 3

ER -

6,7,14,15-Tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole. Synthesis of a novel pentacyclic ring system

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