6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole. Synthesis of a novel pentacyclic ring system

Kittisak Sripha; Darius P. Zlotos; Stefan Buller; Klaus Mohr

doi:10.1016/S0040-4039(03)01796-9

6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole. Synthesis of a novel pentacyclic ring system

Kittisak Sripha
, Darius P. Zlotos
, Stefan Buller
, Klaus Mohr

Universität Würzburg
University of Bonn

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M₂ receptors, a novel heterocyclic ring system, 6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole, has been synthesized. The new ring skeleton was obtained from indol-2-yl-acetic acid in three steps.

Original language	English
Pages (from-to)	7183-7186
Number of pages	4
Journal	Tetrahedron Letters
Volume	44
Issue number	38
DOIs	https://doi.org/10.1016/S0040-4039(03)01796-9
Publication status	Published - 15 Sept 2003
Externally published	Yes

Keywords

6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole
Dimerization of 2-(indol-2-yl)-ethyl tosylate
Ligands for the allosteric binding site of muscarinic M2 receptors
Novel pentacyclic ring system

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10.1016/S0040-4039(03)01796-9

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title = "6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole. Synthesis of a novel pentacyclic ring system",

abstract = "In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M2 receptors, a novel heterocyclic ring system, 6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole, has been synthesized. The new ring skeleton was obtained from indol-2-yl-acetic acid in three steps.",

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author = "Kittisak Sripha and Zlotos, \{Darius P.\} and Stefan Buller and Klaus Mohr",

year = "2003",

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doi = "10.1016/S0040-4039(03)01796-9",

language = "English",

volume = "44",

pages = "7183--7186",

journal = "Tetrahedron Letters",

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T1 - 6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole. Synthesis of a novel pentacyclic ring system

AU - Sripha, Kittisak

AU - Zlotos, Darius P.

AU - Buller, Stefan

AU - Mohr, Klaus

PY - 2003/9/15

Y1 - 2003/9/15

N2 - In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M2 receptors, a novel heterocyclic ring system, 6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole, has been synthesized. The new ring skeleton was obtained from indol-2-yl-acetic acid in three steps.

AB - In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M2 receptors, a novel heterocyclic ring system, 6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole, has been synthesized. The new ring skeleton was obtained from indol-2-yl-acetic acid in three steps.

KW - 6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole

KW - Dimerization of 2-(indol-2-yl)-ethyl tosylate

KW - Ligands for the allosteric binding site of muscarinic M2 receptors

KW - Novel pentacyclic ring system

UR - https://www.scopus.com/pages/publications/0041508448

U2 - 10.1016/S0040-4039(03)01796-9

DO - 10.1016/S0040-4039(03)01796-9

M3 - Article

AN - SCOPUS:0041508448

SN - 0040-4039

VL - 44

SP - 7183

EP - 7186

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 38

ER -

6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole. Synthesis of a novel pentacyclic ring system

Abstract

Keywords

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