3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus

Ratana Lawung; Lertyot Treeratanapiboon; Supaluk Prachayasittikul; Virapong Prachayasittikul

doi:10.2174/157018010792929603

3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus

Ratana Lawung
, Lertyot Treeratanapiboon
, Supaluk Prachayasittikul
, Virapong Prachayasittikul

Srinakharinwirot University
Mahidol University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In a previous study, 5-(1-adamantylthio)-3-picoline (I) and 3-(1-adamantylthio)-4-phenylpyridine (II) were shown to have potent antimicrobial activity. The present investigation is concerned with the antimicrobial action of thiopyridines I and II against methicillin-resistant Staphylococcus aureus (MRSA) isolates and with their murine fibroblast (L929) cytotoxicity. Thiopyridine II was found to display significant antimicrobial activity against all of the MRSA isolates tested, with minimum inhibitory concentrations (MIC) of 1-8 μg/mL. Moreover, both I and II attenuate the viability of L929 cells in a dose-dependent manner, displaying an IC₅₀ of 68.4±6.0 and 47.3±5.6 μg/mL, respectively. These findings suggest that thiopyridine II is promising as a lead compound for further development as a therapeutic.

Original language	English
Pages (from-to)	674-678
Number of pages	5
Journal	Letters in Drug Design and Discovery
Volume	7
Issue number	9
DOIs	https://doi.org/10.2174/157018010792929603
Publication status	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3-(1-adamantylthio)-4-phenylpyridine
Antimicrobial activity
MTT assay
Methicillin resistant staphylococcus aureus
Susceptibility testing

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10.2174/157018010792929603

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@article{31a9746bd2d2469fa092defd97738882,

title = "3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus",

abstract = "In a previous study, 5-(1-adamantylthio)-3-picoline (I) and 3-(1-adamantylthio)-4-phenylpyridine (II) were shown to have potent antimicrobial activity. The present investigation is concerned with the antimicrobial action of thiopyridines I and II against methicillin-resistant Staphylococcus aureus (MRSA) isolates and with their murine fibroblast (L929) cytotoxicity. Thiopyridine II was found to display significant antimicrobial activity against all of the MRSA isolates tested, with minimum inhibitory concentrations (MIC) of 1-8 μg/mL. Moreover, both I and II attenuate the viability of L929 cells in a dose-dependent manner, displaying an IC50 of 68.4±6.0 and 47.3±5.6 μg/mL, respectively. These findings suggest that thiopyridine II is promising as a lead compound for further development as a therapeutic.",

keywords = "3-(1-adamantylthio)-4-phenylpyridine, Antimicrobial activity, MTT assay, Methicillin resistant staphylococcus aureus, Susceptibility testing",

author = "Ratana Lawung and Lertyot Treeratanapiboon and Supaluk Prachayasittikul and Virapong Prachayasittikul",

year = "2010",

doi = "10.2174/157018010792929603",

language = "English",

volume = "7",

pages = "674--678",

journal = "Letters in Drug Design and Discovery",

issn = "1570-1808",

publisher = "KeAi Communications Co.",

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}

TY - JOUR

T1 - 3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus

AU - Lawung, Ratana

AU - Treeratanapiboon, Lertyot

AU - Prachayasittikul, Supaluk

AU - Prachayasittikul, Virapong

PY - 2010

Y1 - 2010

N2 - In a previous study, 5-(1-adamantylthio)-3-picoline (I) and 3-(1-adamantylthio)-4-phenylpyridine (II) were shown to have potent antimicrobial activity. The present investigation is concerned with the antimicrobial action of thiopyridines I and II against methicillin-resistant Staphylococcus aureus (MRSA) isolates and with their murine fibroblast (L929) cytotoxicity. Thiopyridine II was found to display significant antimicrobial activity against all of the MRSA isolates tested, with minimum inhibitory concentrations (MIC) of 1-8 μg/mL. Moreover, both I and II attenuate the viability of L929 cells in a dose-dependent manner, displaying an IC50 of 68.4±6.0 and 47.3±5.6 μg/mL, respectively. These findings suggest that thiopyridine II is promising as a lead compound for further development as a therapeutic.

AB - In a previous study, 5-(1-adamantylthio)-3-picoline (I) and 3-(1-adamantylthio)-4-phenylpyridine (II) were shown to have potent antimicrobial activity. The present investigation is concerned with the antimicrobial action of thiopyridines I and II against methicillin-resistant Staphylococcus aureus (MRSA) isolates and with their murine fibroblast (L929) cytotoxicity. Thiopyridine II was found to display significant antimicrobial activity against all of the MRSA isolates tested, with minimum inhibitory concentrations (MIC) of 1-8 μg/mL. Moreover, both I and II attenuate the viability of L929 cells in a dose-dependent manner, displaying an IC50 of 68.4±6.0 and 47.3±5.6 μg/mL, respectively. These findings suggest that thiopyridine II is promising as a lead compound for further development as a therapeutic.

KW - 3-(1-adamantylthio)-4-phenylpyridine

KW - Antimicrobial activity

KW - MTT assay

KW - Methicillin resistant staphylococcus aureus

KW - Susceptibility testing

UR - https://www.scopus.com/pages/publications/77958499309

U2 - 10.2174/157018010792929603

DO - 10.2174/157018010792929603

M3 - Article

AN - SCOPUS:77958499309

SN - 1570-1808

VL - 7

SP - 674

EP - 678

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

IS - 9

ER -

3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus

Abstract

UN SDGs

Keywords

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