Dr. Rathanin Seng is a microbiologist and molecular epidemiology researcher affiliated with the Department of Medical Science, Mahidol University, Amnat Charoen Campus. His research focuses on bacterial infectious diseases, antimicrobial resistance, environmental microbiology, and genomic epidemiology, particularly Burkholderia pseudomallei, the causative agent of melioidosis. His work integrates molecular diagnostics, whole-genome sequencing, and bioinformatics to investigate pathogen diversity, transmission, and environmental reservoirs. Dr. Seng has contributed to several collaborative international studies and has published research on melioidosis, antimicrobial-resistant staphylococci, and bacterial genomics, supporting improved infectious disease surveillance and public health responses in Southeast Asia.

Antibiotic resistance, virulence, and diagnostic targets of B. pseudomallei

1)      Suttisak, D., Cagape, C. M. S., Seng, R., Saiprom, N., Boonyanugomol, W., Rukseree, K., ... & Chantratita, N. (2026). Evaluation of culture-and PCR-based methods for detecting Burkholderia pseudomallei in soil samples in Thailand. PLOS Neglected Tropical Diseases, 20(1), e0013840

2)      Seng, R., Chomkatekaew, C., Tandhavanant, S. et al. Genetic diversity, determinants, and dissemination of Burkholderia pseudomallei lineages implicated in melioidosis in Northeast Thailand. Nat Commun 15, 5699 (2024). https://doi.org/10.1038/s41467-024-50067-9

3)      Indrawattana, N., Santajit, S., Seng, R., Rungruengkitkun, A., Kong-Ngoen, T., Tunyong, W., ... & Pumirat, P. (2025). Deciphering the diversity, structure, and function of cycle-inhibiting factor in Burkholderia pseudomallei neuroinfection. Science Progress, 108(3), 00368504251369011.

4)      Bragginton, É. C., Colenso, C. K., Calvopiña, K., Hinchliffe, P., Shaw, J. M., Tooke, C. L., Seng, R ... & Spencer, J, (2024). Structure and dynamics of Burkholderia pseudomallei OXA-57, a distinctive low efficiency class D β-lactamase with carbapenem-hydrolyzing activity. bioRxiv, 2024-12.

5)      Seng, R., Phunpang, R., Saiprom, N., Dulsuk, A., Chewapreecha, C., Thaipadungpanit, J., ... & Chantratita, N. (2023). Phenotypic and genetic alterations of Burkholderia pseudomallei in patients during relapse and persistent infections. Frontiers in Microbiology, 14.

6)      Cagape, C. M. S., Seng, R., Saiprom, N., Tandhavanant, S., Chewapreecha, C., Boonyuen, U., ... & Chantratita, N. (2024). Genetic variation, structural analysis, and virulence implications of BimA and BimC in clinical isolates of Burkholderia pseudomallei in Thailand. Scientific Reports, 14(1), 24966.

7)      Vannachone, S., Luangraj, M., Dance, D., Chantratita, N., Saiprom, N., Seng, R., ... & Roberts, T. (2024). Case Report: Soft tissue infection with Burkholderia thailandensis capsular variant: case report from the Lao PDR. Wellcome Open Research, 9, 421.

8)      Noparatvarakorn C, Jakkul W, Seng R, Tandhavanant S, Ottiwet O, Janon R, Saikong W, Chantratita N. 2023. Optimization and prospective evaluation of sensitive real-time PCR assays with an internal control for the diagnosis of melioidosis in Thailand. Microbiol Spectr 11:e01039-23.

9)      Wongpalee, S. P., Thananchai, H., Chewapreecha, C., Roslund, H. B., Chomkatekaew, C., Tananupak, W., Boonklang P., Pakdeerat S., Seng, R., ... & Khamnoi, P. (2022). Highly specific and sensitive detection of Burkholderia pseudomallei genomic DNA by CRISPR-Cas12a. PLOS Neglected Tropical Diseases, 16(8), e0010659. 

10) Fen SHY, Tandhavanant S, Phunpang R, Ekchariyawat P, Saiprom N, Chewapreecha C, Seng R, Thiansukhon E, Morakot C, Sangsa N, Chayangsu S, Chuananont S, Tanwisaid K, Silakun W, Buasi N, Chaisuksant S, Hompleum T, Chetchotisakd P, Day NPJ, Chantratita W, Lertmemongkolchai G, West TE, Chantratita N. Antibiotic susceptibility of clinical Burkholderia pseudomallei isolates in northeast Thailand during 2015-2018 and the genomic characterization of β-lactam-resistant isolates. Antimicrob Agents Chemother.